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Serum Tears for dry eye

Eye drops produced from a patient's blood serum and used for selected severe ocular-surface conditions.

What is Serum Tears?

Autologous serum tears are made from the liquid serum portion of a patient's blood. Their composition includes proteins and growth factors also found in natural tears.

How it works

A blood collection and compounding process produces diluted or undiluted eye drops. Patients follow strict frozen or refrigerated storage instructions.

Potential benefits

  • Support the ocular surface in severe or persistent dry eye
  • Improve comfort and surface staining for some patients
  • Provide an option when standard lubricants are insufficient

Risks and limitations

  • Access, cost, blood draws, storage, and frequent dosing can be burdensome
  • Contamination and handling errors are possible
  • Preparation protocols and results vary

Questions to ask a clinic

Which concentration and preparation protocol do you use?

How should the drops be stored and discarded?

What findings from my eye examination support this treatment?

What alternatives should I consider first?

How will we measure whether it is helping?

What will the total treatment and follow-up cost be?

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Related treatments

References

  1. Autologous serum eye drops for dry eye Cochrane Database of Systematic Reviews
  2. TFOS DEWS II Management and Therapy Report The Ocular Surface

Last reviewed June 11, 2026. This page is educational and does not provide medical advice. Discuss diagnosis, suitability, risks, and alternatives with a qualified eye-care professional.